A three-dimensional Hellinger-Reissner Virtual Element Method for linear elasticity problems

We present a Virtual Element Method for the 3D linear elasticity problems, based on Hellinger-Reissner variational principle. In the framework of the small strain theory, we propose a low-order scheme with a-priori symmetric stresses and continuous tractions across element interfaces. A convergence and stability analysis is developed and we confirm the theoretical predictions via some numerical tests.Comment: submitted to CMAM

SUPG-stabilized Virtual Elements for diffusion-convection problems: a robustness analysis

The objective of this contribution is to develop a convergence analysis for SUPG-stabilized Virtual Element Methods in diffusion-convection problems that is robust also in the convection dominated regime. For the original method introduced in [Benedetto et al, CMAME 2016] we are able to show an "almost uniform" error bound (in the sense that the unique term that depends in an unfavorable way on the parameters is damped by a higher order mesh-size multiplicative factor). We also introduce a novel discretization of the convection term that allows us to develop error estimates that are fully robust in the convection dominated cases. We finally present some numerical result

To What Extent Can UAV Photogrammetry Replicate UAV LiDAR to Determine Forest Structure? A Test in Two Contrasting Tropical Forests

Tropical forests are complex multi-layered systems, with the height and three-dimensional (3D) structure of trees influencing the carbon and biodiversity they contain. Fine-resolution 3D data on forest structure can be collected reliably with Light Detection and Ranging (LiDAR) sensors mounted on aircraft or Unoccupied Aerial Vehicles (UAVs), however, they remain expensive to collect and process. Structure-from-Motion (SfM) Digital Aerial Photogrammetry (SfM-DAP), which relies on photographs taken of the same area from multiple angles, is a lower-cost alternative to LiDAR for generating 3D data on forest structure. Here, we evaluate how SfM-DAP compares to LiDAR data acquired concurrently using a fixed-wing UAV, over two contrasting tropical forests in Gabon and Peru. We show that SfM-DAP data cannot be used in isolation to measure key aspects of forest structure, including canopy height (%Bias: 40%–50%), fractional cover, and gap fraction, due to difficulties measuring ground elevation, even under low tree cover. However, we find even in complex forests, SfM-DAP is an effective means of measuring top-of-canopy structure, including surface heterogeneity, and is capable of producing similar measurements of vertical structure as LiDAR. Thus, in areas where ground height is known, SfM-DAP is an effective method for measuring important aspects of forest structure, including canopy height, and gaps, however, without ground data, SfM-DAP is of more limited utility. Our results support the growing evidence base pointing to photogrammetry as a viable complement, or alternative, to LiDAR, capable of providing much needed information to support the mapping and monitoring of biomass and biodiversity

Digestibilidade de dietas com diferentes formas físicas para frangos de corte.

A peletização é o processamento térmico mais utilizado na indústria avícola, pois favorece o aproveitamento dos ingredientes e modifica a forma física da dieta. A pressão, umidade e temperatura empregadas por determinado tempo no processo, promovem alterações nas estruturas dos carboidratos, bem como das proteínas. O objetivo desse estudo foi avaliar o efeito de diferentes formas físicas (farelada ou peletizada/triturada com diferentes tempos de condicionamento) sobre o coeficiente de digestibilidade ileal aparente da matéria seca (CDIAMS), proteína bruta (CDIAPB) e energia digestível ileal (EDI) em frangos de corte de 1 a 25 dias

Coeficiente de metabolizabilidade aparente de diferentes fontes lipídicas com ou sem emulsificante para frangos de corte de 1 a 8 dias.

Óleos e gorduras são utilizados nas rações de aves devido às suas altas concentrações calóricas. Entretanto, a escolha da fonte lipídica a ser utilizada na formulação dependerá de seu custo e da qualidade. O uso de emulsificantes em aves jovens tem o objetivo de auxiliar na digestão e absorção da gordura da dieta devido à imaturidade da circulação entero-hepática nesses animais (5). O objetivo do estudo foi avaliar o coeficiente de metabolizabilidade aparente da matéria seca (CMAMS) e extrato etéreo (CMAEE) e energia metabolizável (EM) em frangos de corte de 1 a 8 dias de idade alimentados com diferentes fontes lipídicas com ou sem a adição de emulsificantes

Human dyskerin binds to cytoplasmic H/ACA-box-containing transcripts affecting nuclear hormone receptor dependence

Background Dyskerin is a nuclear protein involved in H/ACA box snoRNA-guided uridine modification of RNA. In humans, its defective function is associated with cancer development and induces specific post-transcriptional alterations of gene expression. In this study, we seek to unbiasedly identify mRNAs regulated by dyskerin in human breast cancer-derived cells. Results We find that dyskerin depletion affects the expression and the association with polysomes of selected mRNA isoforms characterized by the retention of H/ACA box snoRNA-containing introns. These snoRNA retaining transcripts (snoRTs) are bound by dyskerin in the cytoplasm in the form of shorter 3 ' snoRT fragments. We then characterize the whole cytoplasmic dyskerin RNA interactome and find both H/ACA box snoRTs and protein-coding transcripts which may be targeted by the snoRTs' guide properties. Since a fraction of these protein-coding transcripts is involved in the nuclear hormone receptor binding, we test to see if this specific activity is affected by dyskerin. Obtained results indicate that dyskerin dysregulation may alter the dependence on nuclear hormone receptor ligands in breast cancer cells. These results are paralleled by consistent observations on the outcome of primary breast cancer patients stratified according to their tumor hormonal status. Accordingly, experiments in nude mice show that the reduction of dyskerin levels in estrogen-dependent cells favors xenograft development in the absence of estrogen supplementation. Conclusions Our work suggests a cytoplasmic function for dyskerin which could affect mRNA post-transcriptional networks relevant for nuclear hormone receptor functions

Pain and Frailty in Hospitalized Older Adults

Introduction: Pain and frailty are prevalent conditions in the older population. Many chronic diseases are likely involved in their origin, and both have a negative impact on quality of life. However, few studies have analysed their association. Methods: In light of this knowledge gap, 3577 acutely hospitalized patients 65 years or older enrolled in the REPOSI register, an Italian network of internal medicine and geriatric hospital wards, were assessed to calculate the frailty index (FI). The impact of pain and some of its characteristics on the degree of frailty was evaluated using an ordinal logistic regression model after adjusting for age and gender. Results: The prevalence of pain was 24.7%, and among patients with pain, 42.9% was regarded as chronic pain. Chronic pain was associated with severe frailty (OR = 1.69, 95% CI 1.38–2.07). Somatic pain (OR = 1.59, 95% CI 1.23–2.07) and widespread pain (OR = 1.60, 95% CI 0.93–2.78) were associated with frailty. Osteoarthritis was the most common cause of chronic pain, diagnosed in 157 patients (33.5%). Polymyalgia, rheumatoid arthritis and other musculoskeletal diseases causing chronic pain were associated with a lower degree of frailty than osteoarthritis (OR = 0.49, 95%CI 0.28–0.85). Conclusions: Chronic and somatic pain negatively affect the degree of frailty. The duration and type of pain, as well as the underlying diseases associated with chronic pain, should be evaluated to improve the hospital management of frail older people

The multifaceted spectrum of liver cirrhosis in older hospitalised patients: Analysis of the REPOSI registry

Background: Knowledge on the main clinical and prognostic characteristics of older multimorbid subjects with liver cirrhosis (LC) admitted to acute medical wards is scarce. Objectives: To estimate the prevalence of LC among older patients admitted to acute medical wards and to assess the main clinical characteristics of LC along with its association with major clinical outcomes and to explore the possibility that well-distinguished phenotypic profiles of LC have classificatory and prognostic properties. Methods: A cohort of 6,193 older subjects hospitalised between 2010 and 2018 and included in the REPOSI registry was analysed. Results: LC was diagnosed in 315 patients (5%). LC was associated with rehospitalisation (age-sex adjusted hazard ratio, [aHR] 1.44; 95% CI, 1.10-1.88) and with mortality after discharge, independently of all confounders (multiple aHR, 2.1; 95% CI, 1.37-3.22), but not with in-hospital mortality and incident disability. Three main clinical phenotypes of LC patients were recognised: relatively fit subjects (FIT, N = 150), subjects characterised by poor social support (PSS, N = 89) and, finally, subjects with disability and multimorbidity (D&M, N = 76). PSS subjects had an increased incident disability (35% vs 13%, P < 0.05) compared to FIT. D&M patients had a higher mortality (in-hospital: 12% vs 3%/1%, P < 0.01; post-discharge: 41% vs 12%/15%, P < 0.01) and less rehospitalisation (10% vs 32%/34%, P < 0.01) compared to PSS and FIT. Conclusions: LC has a relatively low prevalence in older hospitalised subjects but, when present, accounts for worse post-discharge outcomes. Phenotypic analysis unravelled the heterogeneity of LC older population and the association of selected phenotypes with different clinical and prognostic features